2F-DCK (2-Fluorodeschloroketamine)

2F-DCK (2-Fluorodeschloroketamine): Comprehensive Product Overview

Introduction to 2F-DCK (2-Fluorodeschloroketamine)

2F-DCK (2-Fluorodeschloroketamine) is a dissociative arylcyclohexylamine belonging to the same chemical family as ketamine and deschloroketamine (DCK). It has gained notable attention in the scientific community for its unique pharmacological profile and structural similarity to ketamine, making it an important subject of research in neuropharmacology, receptor binding studies, and behavioral neuroscience.

Researchers often study 2F-DCK(2-Fluorodeschloroketamine) for its NMDA receptor antagonist activity, which is believed to contribute to its dissociative effects and potential therapeutic mechanisms. Its chemical structure, which includes a fluorine atom substitution, alters its lipophilicity and metabolism, providing a valuable comparison model for understanding how halogen substitution influences arylcyclohexylamine pharmacodynamics.

Chemical Name: 2-Fluorodeschloroketamine
Common Names: 2F-DCK, Fluoroketamine, 2-Fl-2’-Oxo-PCM
Chemical Formula: C13H16FNO
Molecular Weight: 221.27 g/mol
IUPAC Name: (R,S)-2-(2-Fluorophenyl)-2-methylamino-cyclohexanone
Purity: ≥ 98% (analytical standard grade)
Form: Crystalline powder
Intended Use: Laboratory and forensic research purposes only

Chemical and Structural Properties of 2F-DCK (2-Fluorodeschloroketamine)

2F-DCK(2-Fluorodeschloroketamine) is structurally related to ketamine (2-chloroketamine), with the primary difference being the replacement of the chlorine atom in ketamine’s phenyl ring with a fluorine atom. This seemingly minor alteration results in significant changes in receptor binding affinity, potency, and metabolic stability.

• CAS Number: Not assigned (research chemical)

• Class: Arylcyclohexylamine dissociative

• Appearance: Off-white to light crystalline powder

• Solubility: Soluble in ethanol, methanol, and dimethyl sulfoxide (DMSO); slightly soluble in water

• Storage Conditions: Store in a cool, dry place, protected from light and moisture. Recommended temperature: below 25°C

This compound’s high analytical purity ensures that it is suitable for precise qualitative and quantitative analysis in controlled laboratory environments.

Pharmacological Background of 2F-DCK (2-Fluorodeschloroketamine)

While 2F-DCK(2-Fluorodeschloroketamine) is not approved for human or veterinary use, it remains an important research analog for understanding the mechanism of action of NMDA receptor antagonists. Studies suggest that 2F-DCK interacts primarily with:

• N-methyl-D-aspartate (NMDA) receptors – acting as a non-competitive antagonist

• Sigma receptors – potentially contributing to psychoactive and neuroprotective effects

• Dopaminergic and serotonergic systems – though to a lesser degree, offering insight into its broader neurochemical interactions

Researchers investigating 2F-DCK(2-Fluorodeschloroketamine) often focus on its comparative efficacy, receptor affinity, and metabolism relative to ketamine and DCK. Its longer half-life and altered potency provide valuable data for pharmacokinetic modeling and structure-activity relationship (SAR) studies.

Applications in Research 2F-DCK (2-Fluorodeschloroketamine)

2F-DCK is utilized across multiple research fields, including:

1. Pharmacological Studies
   Used to explore NMDA receptor function, ion channel modulation, and neural plasticity.

2. Behavioral and Cognitive Research
   2F-DCK(2-Fluorodeschloroketamine) serves as a model for dissociation, perception alteration, and neurocognitive modulation in controlled experiments.

3. Analytical Chemistry and Forensic Testing
   Researchers employ 2F-DCK as a reference material for mass spectrometry, chromatography, and toxicological profiling.

4. Structure-Activity Relationship (SAR) Studies
   The fluorine substitution provides valuable data for developing next-generation NMDA receptor antagonists with optimized efficacy and safety.

Safety and Handling Information 2F-DCK (2-Fluorodeschloroketamine)

2F-DCK(2-Fluorodeschloroketamine) should only be handled by trained professionals in equipped laboratories. Proper safety procedures, including the use of gloves, protective eyewear, and laboratory coats, are essential.
This compound is not for human consumption, medical treatment, or recreational use. Ingestion or misuse may result in serious health risks.

Safety Recommendations:

• Avoid inhalation or contact with skin and eyes.

• Store securely, away from heat and direct sunlight.

• Dispose of unused material following local chemical safety regulations.

Legal and Regulatory Status

The legal classification of 2F-DCK(2-Fluorodeschloroketamine) varies by country and jurisdiction. In many regions, it remains an uncontrolled research chemical, while others have implemented specific analog acts or psychoactive substance regulations that may apply to compounds structurally similar to ketamine.

Researchers are strongly advised to verify local and international regulations before purchase, import, or use of 2F-DCK in any project.

Why Choose High-Quality 2F-DCK (2-Fluorodeschloroketamine) for Research

When conducting scientific research, compound purity and authenticity are critical. High-quality 2F-DCK ensures:

• Reliable and reproducible analytical results

• Accurate pharmacological modeling

• Enhanced safety in controlled experiments

• Confidence in structural and receptor-based studies

Reputable suppliers provide batch-specific Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) for full transparency.

Conclusion

2F-DCK (2-Fluorodeschloroketamine) represents a valuable addition to the expanding library of arylcyclohexylamine research compounds. Its unique fluorine substitution makes it a key analog for investigating NMDA receptor modulation, dissociative pharmacology, and structure-function relationships among ketamine derivatives.

For laboratory and forensic researchers, 2F-DCK(2-Fluorodeschloroketamine) offers a consistent, high-purity standard for analytical, pharmacological, and biochemical studies.

Note: 2F-DCK is sold strictly for laboratory research purposes only. It is not intended for human or veterinary use. Ensure compliance with all applicable laws and regulations before ordering or handling.