25B-NBOMe

25B-NBOMe – High-Purity Research Chemical for Analytical Use

Overview of 25B-NBOMe

25B-NBOMe is a potent synthetic phenethylamine derivative belonging to the NBOMe (N-benzyl-oxy-methyl) series, which also includes compounds such as 25I-NBOMe and 25C-NBOMe. These compounds are recognized for their high receptor selectivity and unique pharmacological profiles, making them valuable for neuroscientific and receptor-binding studies.

Developed in the early 2000s during academic research into 2C-series phenethylamines, 25B-NBOMe acts primarily as a 5-HT2A receptor agonist, a receptor subtype in the serotonin family that plays a critical role in cognition, perception, and mood regulation. This makes it a compound of significant interest for receptor mapping and behavioral pharmacology research.

Chemical Name: 2-(4-Bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
Common Name: 25B-NBOMe
Molecular Formula: C18H22BrNO3
Molecular Weight: 380.28 g/mol
Form: Powder or crystalline solid
Purity: ≥ 98% (HPLC verified)
Intended Use: Laboratory and analytical research only

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Chemical and Structural Characteristics

NBOMe (N-benzyl-oxy-methyl) is structurally derived from 2C-B (4-bromo-2,5-dimethoxyphenethylamine) by adding an N-(2-methoxybenzyl) group to the amine. This modification significantly increases its binding affinity for serotonin receptors, especially the 5-HT2A receptor, often resulting in sub-nanomolar potency.

Key physicochemical properties include:

• Appearance: Off-white crystalline powder

• Solubility: Soluble in ethanol, dimethyl sulfoxide (DMSO), and other organic solvents

• Stability: Stable under dry, cool, and light-protected storage conditions

• Storage Recommendations: Store at 2–8°C, tightly sealed, and away from direct sunlight

These properties make 25B-NBOMe ideal for analytical research, such as liquid chromatography (LC), mass spectrometry (MS), and receptor binding assays.

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Applications and Research Significance

NBOMe (N-benzyl-oxy-methyl) has gained considerable interest among pharmacologists, neuroscientists, and analytical chemists for its high potency and selectivity at serotonin receptor subtypes. Some of its common research applications include:

1. Receptor Binding Studies

25B-NBOMe is frequently utilized to explore the 5-HT2A receptor binding mechanisms. Due to its high affinity, it allows researchers to study how serotonin agonists interact with neural receptors involved in sensory processing, cognition, and mood.

2. Structure-Activity Relationship (SAR) Analysis

By comparing 25B-NBOMe with analogs like 25I-NBOMe and 25C-NBOMe, scientists can analyze structure–activity relationships within the NBOMe family. This data helps understand how halogen substitution affects potency, efficacy, and receptor selectivity.

3. Pharmacokinetic and Metabolic Profiling

25B-NBOMe also provides a model for studying drug metabolism in vitro. Analytical studies often focus on how the compound is metabolized by cytochrome P450 enzymes, generating valuable insights for toxicology and biochemical research.

4. Spectroscopic and Analytical Reference

Because of its well-defined chemical structure, 25B-NBOMe serves as a reference standard for chromatographic calibration, mass spectral analysis, and forensic toxicology applications. Researchers use it to identify and compare similar compounds in biological or environmental samples.

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Safety, Handling, and Legal Notice

Important Notice:
25B-NBOMe is a research chemical and not approved for human consumption. It is not intended for veterinary or therapeutic use. All handling should be performed by qualified personnel in a controlled laboratory setting equipped with appropriate protective equipment.

Safety Guidelines:

• Avoid inhalation, ingestion, or skin contact.

• Always use gloves, protective eyewear, and lab coats.

• Store securely, away from unauthorized access.

Legal Status:
The legality of 25B-NBOMe varies by jurisdiction. In some countries, it is classified as a controlled substance due to its psychoactive potential. Researchers are responsible for ensuring compliance with local, state, and federal regulations before purchase or use.

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Why Choose High-Quality 25B-NBOMe for Research?

When sourcing 25B-NBOMe, purity and authenticity are crucial for reproducible research results. High-quality 25B-NBOMe ensures:

• Consistent analytical outcomes in chromatography and spectroscopy.

• Reliable receptor binding data due to accurate molecular integrity.

• Reduced risk of contamination or unwanted byproducts.

Our 25B-NBOMe is laboratory-tested and HPLC-verified, offering researchers the assurance of superior chemical quality and verified composition. Each batch includes detailed certificate of analysis (COA) and safety data sheet (SDS) to support compliance and traceability.

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Storage and Stability Recommendations

To maintain maximum stability and shelf life:

• Keep the product in a tightly sealed container.

• Store at 2–8°C in a dry environment.

• Avoid exposure to direct sunlight and humidity.

• Handle only under low-light laboratory conditions.

When stored correctly, 25B-NBOMe retains its structural integrity for extended periods, ensuring consistent performance across analytical applications.

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Summary

25B-NBOMe is a potent, high-affinity serotonin receptor agonist that has become an essential compound in receptor binding and neurochemical research. With its precise structure, high purity, and reproducible effects, it continues to play a key role in expanding our understanding of serotonin signaling, psychopharmacology, and structure–activity relationships within the phenethylamine class.

Whether used for analytical calibration, neuroscience experiments, or toxicological research, 25B-NBOMe remains one of the most valuable NBOMe compounds available to the scientific community — provided it is handled responsibly and within legal and ethical guidelines.

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Disclaimer:
This product is sold strictly for research and analytical purposes only. It is not for human or animal consumption. Always comply with your local laws and regulations before purchase or use.